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Dec 11, 2020 Company News

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Testimonials

Green Bioactives Ltd aim to develop plant cell culture as a platform to manufacture safe and sustainable plant biomolecules. We grew plant cells using different types of microbial/mammalian cell culture systems, including a 2.5 L stirred bioreactor and a 20L rocking motion bioreactor. We experienced relatively slow plant cell growth rates and a high risk of culture contamination using these two systems.... we came across the Cellexus CellMaker when we were looking to evaluate airlift bioreactors. During the first run in the CellMaker, our plant cells displayed growth rates comparable to the growth rate achieved using shaking flask liquid culture, with the cells reaching a high density. We are now working to improve the process further, testing the CellMaker system with different cell lines, together with evaluating the yield of target high-value molecules. Read the full testimonial

Samuel Casasola-Zamora, Director of Operations, Green-Bioactives Ltd

Using the Cellexus airlift bioreactor, our goals of scaling-up our mycorrhizal fungi liquid fermentation could be easily realised. The size of the reactor and the single-use aspect of the bag meant that we could utilise the unit within our laboratory with minimal effort required.The dissolved oxygen and pH monitoring and control allowed us to characterise our organisms' growth characteristics and has informed our decisions on further scaling-up in the future.

Alex Leman, Bioprocess Engineer, Rhizocore Technologies

We are a small company that needed to quickly upscale. We were looking to increase our production for some large-scale trials, so we were looking for a bioreactor that is easy to manage and set up, but we didn’t have autoclaving facilities. The Cellexus CellMaker ticked all these boxes: we got an increased phage yield, it is compact, the simple interface means we could set it up and leave it alone, plus the sterilised disposable bags cuts out any contamination risks. This will be important for us as we move into practices that require more stringent manufacturing processes, such as the medical field. We have had some fantastic results, increasing our phage production to 1 x 10^13 pfu / ml.

Gordon Smith, Fixed Phage

The CellMaker system has allowed us to grow in scale and to achieve higher productivity. Instead of scaling “out” by using several flasks, we can combine it all in one bag inside the bioreactor. In the 8L bioreactor we can easily get between 3 and 8 litres of phage lysate, and in the 50L bioreactor somewhere between 10 and 50 litres in one go, and with higher phage concentration per unit of volume. The CellMaker was the most cost-effective option on the market for a single-use system with temperature control. It is one of the least expensive I have heard about, and this goes for the bioreactor bags as well. When you balance the cost-benefit, the CellMaker is a good option for phage biotechs.

Dr. Manuel Garrido, Production Specialist, TechnoPhage

We have found the CellMaker reliable, easy to use and invaluable in our antibody production process, with minimal labour required. Our qualified team likes working with this bioreactor, using the advantages of disposable technologies and its precise regulation of biochemical parameters (pH, pO2, temperature). At low-cost and with low labour, the CellMaker rapidly produces large quantities of high-quality antibodies with high specific activity. The CellMaker system is a vital part of the production process of our innovative and unique p53 antibodies.

Dr Jean-Christophe Bourdon, Principal investigator, Head of p53 isoform research group, University of Dundee

We have found the CellMaker reliable, easy to use and invaluable in our Pharmaceutical processes. Our qualified team likes working with this bioreactor, using the advantages of disposable technologies. The CellMaker produces the quantity and quality of bacteriophage that we are looking for. The 4 CellMaker systems have become a vital part of a production process of our innovative BAFASAL® product.

Dr. Arkadiusz Wojtasik, Project Director, Proteon Pharmaceuticals S.A.

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