Cellmaker Bioreactor Bags - Cellexus

CellMaker Bioreactor Bags

At the heart of every CellMaker system is our patented single use airlift bioreactor bags which have been designed to meet the most demanding research and production requirements.

All component bioreactor bag materials are fabricated and assembled in ISO Class VII clean room facilities and according to an ISO 13485:2016 certified, and FDA 21CFR 820 compliant, manufacturing process to ensure you are working with a consistently high-quality product.

Once double bagged and gamma irradiated CellMaker bioreactor bags are stored and dispatched to you according to a robust, ISO 9001:2015 accredited, quality management system providing you with ultimate peace of mind.

Further details and quality certificates are available on request.

CellMaker Bioreactor Bags are available in 4, 8 and 50 litre capacities with Regular & Plus configurations available in all sizes.

Benefits of our Bioreactor Bags

CellMaker bioreactor bags combine the well documented benefits and economy of single use bioprocessing with the scaleability and cell culture improvements afforded by super-gentle airlift technology.

Assembling a CellMaker bioreactor takes just a few minutes so you can be ready to culture very quickly without complicated and involved cleaning, assembly and sterilisation processes to get in the way of your productivity.

As CellMaker employs airlift mixing to ensure correct gassing and efficient mixing of your culture not only are there are no mechanical parts, such as motorised impellers, to worry about but the cells have a much happier time in their own personal spa. As we all know, happy cells are productive cells!

Construction

Each CellMaker bioreactor bag is constructed using a super-tough, puncture resistant laminate of biocompatible Low Density Polyethylene (LDPE) and an Ethyl Vinyl Alcohol (EVOH) gas barrier to ensure total control of culture conditions, even anaerobic cultures.

All tubing is PharmaFocus tubing, a high quality platinum cured silicone tubing which provides specifically designed to meet the rigorous demands and regulations of the pharmaceutical industry.

Each CellMaker bioreactor bag is constructed using a super-tough, puncture resistant laminate of biocompatible Low Density Polyethylene (LDPE) and an Ethyl Vinyl Alcohol (EVOH) gas barrier to ensure total control of culture conditions, even anaerobic cultures.

All tubing is PharmaFocus tubing, a high quality platinum cured silicone tubing which provides specifically designed to meet the rigorous demands and regulations of the pharmaceutical industry. 


4L Bioreactors

  • Working volume 1.5-4 litres
  • Use with 8L enclosure

RegularPlus
Top ports44
Probe Ports12
Sample ports11
iDot patch (DO Measurement)NoYes
Media In / Harvest ports11

8L Bioreactors

  • Working volume 3-8 litres
  • Use with 8L enclosure

RegularPlus
# Top ports44
# Probe Ports12
# Sample ports11
iDot patch (DO Measurement)NoYes
Media In / Harvest ports11

50L Bioreactors

  • Working volume 3-8 litres
  • Use with 50L enclosure

RegularPlus
# Top ports44
# Probe Ports12
# Sample ports21
iDot patch (DO measurement)NoYes
Media In / Harvest ports22
+44 (0)1382 666357
enquiries@cellexus.com

Testimonials

Green Bioactives Ltd aim to develop plant cell culture as a platform to manufacture safe and sustainable plant biomolecules. We grew plant cells using different types of microbial/mammalian cell culture systems, including a 2.5 L stirred bioreactor and a 20L rocking motion bioreactor. We experienced relatively slow plant cell growth rates and a high risk of culture contamination using these two systems.... we came across the Cellexus CellMaker when we were looking to evaluate airlift bioreactors. During the first run in the CellMaker, our plant cells displayed growth rates comparable to the growth rate achieved using shaking flask liquid culture, with the cells reaching a high density. We are now working to improve the process further, testing the CellMaker system with different cell lines, together with evaluating the yield of target high-value molecules. Read the full testimonial

Samuel Casasola-Zamora, Director of Operations, Green-Bioactives Ltd

Using the Cellexus airlift bioreactor, our goals of scaling-up our mycorrhizal fungi liquid fermentation could be easily realised. The size of the reactor and the single-use aspect of the bag meant that we could utilise the unit within our laboratory with minimal effort required.The dissolved oxygen and pH monitoring and control allowed us to characterise our organisms' growth characteristics and has informed our decisions on further scaling-up in the future.

Alex Leman, Bioprocess Engineer, Rhizocore Technologies

We are a small company that needed to quickly upscale. We were looking to increase our production for some large-scale trials, so we were looking for a bioreactor that is easy to manage and set up, but we didn’t have autoclaving facilities. The Cellexus CellMaker ticked all these boxes: we got an increased phage yield, it is compact, the simple interface means we could set it up and leave it alone, plus the sterilised disposable bags cuts out any contamination risks. This will be important for us as we move into practices that require more stringent manufacturing processes, such as the medical field. We have had some fantastic results, increasing our phage production to 1 x 10^13 pfu / ml.

Gordon Smith, Fixed Phage

The CellMaker system has allowed us to grow in scale and to achieve higher productivity. Instead of scaling “out” by using several flasks, we can combine it all in one bag inside the bioreactor. In the 8L bioreactor we can easily get between 3 and 8 litres of phage lysate, and in the 50L bioreactor somewhere between 10 and 50 litres in one go, and with higher phage concentration per unit of volume. The CellMaker was the most cost-effective option on the market for a single-use system with temperature control. It is one of the least expensive I have heard about, and this goes for the bioreactor bags as well. When you balance the cost-benefit, the CellMaker is a good option for phage biotechs.

Dr. Manuel Garrido, Production Specialist, TechnoPhage

We have found the CellMaker reliable, easy to use and invaluable in our antibody production process, with minimal labour required. Our qualified team likes working with this bioreactor, using the advantages of disposable technologies and its precise regulation of biochemical parameters (pH, pO2, temperature). At low-cost and with low labour, the CellMaker rapidly produces large quantities of high-quality antibodies with high specific activity. The CellMaker system is a vital part of the production process of our innovative and unique p53 antibodies.

Dr Jean-Christophe Bourdon, Principal investigator, Head of p53 isoform research group, University of Dundee

We have found the CellMaker reliable, easy to use and invaluable in our Pharmaceutical processes. Our qualified team likes working with this bioreactor, using the advantages of disposable technologies. The CellMaker produces the quantity and quality of bacteriophage that we are looking for. The 4 CellMaker systems have become a vital part of a production process of our innovative BAFASAL® product.

Dr. Arkadiusz Wojtasik, Project Director, Proteon Pharmaceuticals S.A.

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