Antibody Production

Scale up your monoclonal antibody production quickly and easily with the CellMaker bioreactor system

Antibody

Recombinant antibody production can be a labour-intensive process with a high risk of contamination. Our CellMaker systems are designed to allow a fast turnaround with minimal downtime but without the risk of contamination, thanks to their sterile, single-use, disposable bioreactor bags.

The CellMaker uses our revolutionary airlift technology delivering a low air flow for extremely gentle mixing of cells sensitive to shear stress. Cellexus, in collaboration with the University of Abertay Dundee have demonstrated the bioreactor’s suitability for recombinant antibody expression in CHO cells. This novel cell culturing system has also been used to grow hybridoma cell lines for monoclonal antibody production.

The CellMaker has been used in scale up of production of antibodies 5-fold compared to the flask culture. Additionally, in E. coli it was possible to scale up the expression of recombinant proteins to higher yields per litre in comparison to flask culture.

CellMaker systems dynamically regulate temperature, pH and dissolved oxygen, as required for cell culture, allowing large scale recombinant antibody production in a small laboratory footprint.

Download our antibody brochure to find out more about how the CellMaker can speed up and simplify recombinant antibody production.

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Antibody

Discover how the CellMaker Plus was used in our Case Study: Hybridoma culture in the CellMaker.

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Read our white paper on how the Low Flow Controller was used to in situ transfect and express recombinant antibody in CHO suspension cells

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Download our antibody brochure to find out more about how the CellMaker can speed up and simplify recombinant antibody production.

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